![]() ![]() ![]() Slowed RTs on correct proactive trials reflected starting bias towards the alternative action, which was overcome before progressing towards action initiation. Furthermore, the state-space locations were predictive of distinct types of errors: failures-to-stop, failures-to-go, and incorrect choices. Under proactive inhibition, GPe population activity occupied state-space locations farther from the trajectory followed during normal movement initiation. Rats selectively engaged proactive inhibition towards specific actions, as shown by slowed reaction times (RTs). Here we investigate population dynamics of rat GPe neurons during preparation-to-stop, stopping, and going. Within the basal ganglia, the globus pallidus pars externa (GPe) has been hypothesized to mediate selective proactive inhibition: being prepared to stop a specific action, if needed. This behavioral inhibition critically relies on frontal cortex - basal ganglia circuits. Flexible behavior requires restraint of actions that are no longer appropriate. ![]()
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